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Apr 29, 2023 · Aß is generated from APP, a type 1 membrane protein, via the action of proteolytic enzymes known as “secretases” because their action results in ...
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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science. 1999;286:735–741. [PubMed] [Google ...
Aug 30, 2021 · γ-secretase is an aspartyl-type protease membrane protein complex and consists of different several components. The catalytic elements of ...
Nov 15, 2007 · Finally, β-secretase activity is insensitive to pepstatin, an inhibitor of many (but not all) aspartic proteases. During 1999–2000, five teams ...
Jul 17, 2017 · Iron-export ferroxidase activity of beta-amyloid precursor protein is inhibited by Zinc in Alzheimer's disease. Cell 2010; 142: 857–67. CAS ...
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Oct 8, 2013 · β-Amyloid precursor protein (APP) and β-site APP cleaving enzyme 1 (BACE1) trafficking is differentially regulated from the site of trans-Golgi ...
-. Basic information · PROTEASE · ALZHEIMER'S DISEASE · ASPARTIC PROTEASE · ASPARTYL PROTEASE · BETA-SECRETASE · GLYCOPROTEIN · HYDROLASE · MEMAPSIN 2 ...
Title: Design and synthesis of potent, orally efficacious hydroxyethylamine derived beta-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors.
Amyloid-beta precursor protein (APP) is an integral membrane protein expressed in many tissues and concentrated in the synapses of neurons.
Jul 8, 2020 · Targeting amyloidogenic processing of APP is still a fundamentally sound strategy to develop disease-modifying AD therapies and recent advance ...